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KMID : 0624620170500010049
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BMB Reports
2017 Volume.50 No. 1 p.49 ~ p.54
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Vitamin C enhances the expression of IL17 in a Jmjd2?dependent manner
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Song Mi-Hye
Nair Varun Sasidharan
Oh Kwon-Ik
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Abstract
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Previously, we reported that vitamin C facilitates the CpG demethylation of Foxp3 enhancer in CD4+Foxp3+ regulatory T cells (Tregs) by enhancing the activity of a DNA demethylase ten-eleven-translocation (Tet). However, it is not clear whether vitamin C affects other helper T cell lineages like T helper type 17 (Th17) cells which are related with Tregs. Here, we show that the expression of interleukin-17A (IL17) increases with the treatment of vitamin C but not with other antioxidants. Interestingly, the upregulation of IL17 was not accompanied by DNA demethylation in Il17 promoter and was independent of Tet enzymes. Rather, vitamin C reduced the trimethylation of histone H3 lysine 9 (H3K9me3) in the regulatory elements of the Il17 locus, and the effects of vitamin C were abrogated by knockdown of jumonji-C domain-containing protein 2 (jmjd2). These results suggest that vitamin C can affect the expression of IL17 by modulating the histone demethylase activity.
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KEYWORD
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H3K9me3, Histone modification, IL17, Jmjd2, Vitamin C
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